Template:PBB/3416

Insulin-degrading enzyme
250px PDB rendering based on 2g47.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2G47, 2G48, 2G49, 2G54, 2G56, 2JBU, 2JG4, 2WBY, 2WC0, 2WK3, 2YPU, 3CWW, 3E4A, 3E4Z, 3E50, 3H44, 3HGZ, 3N56, 3N57, 3OFI, 3QZ2, 4DTT, 4DWK, 4GS8, 4GSC, 4GSF, 4IFH, 4IOF, 4LTE, 4M1C, 4Q5Z, 4QIA, 4RAL
Identifiers
Symbols	IDE ; INSULYSIN
External IDs	OMIM: 146680 MGI: 96412 HomoloGene: 3645 ChEMBL: 1293287 GeneCards: IDE Gene
EC number	3.4.24.56
Gene ontology Molecular function • beta-amyloid binding • glycoprotein binding • metalloendopeptidase activity • receptor binding • protein binding • ATP binding • zinc ion binding • ATPase activity • beta-endorphin binding • peptide binding • protein homodimerization activity • ubiquitin binding • insulin binding Cellular component • extracellular space • nucleus • nucleoplasm • cytoplasm • mitochondrion • peroxisome • peroxisomal matrix • cytosol • plasma membrane • cell surface • cytosolic proteasome complex Biological process • proteolysis • insulin receptor signaling pathway • determination of adult lifespan • bradykinin catabolic process • ubiquitin homeostasis • viral process • protein processing • positive regulation of protein oligomerization • hormone catabolic process • negative regulation of proteolysis • beta-amyloid metabolic process • protein homooligomerization • protein homotetramerization • protein heterooligomerization • proteolysis involved in cellular protein catabolic process • insulin metabolic process • insulin catabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE IDE 203327 at tn.png
File:PBB GE IDE 203328 x at tn.png
File:PBB GE IDE 217496 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3416	15925
Ensembl	ENSG00000119912	ENSMUSG00000056999
UniProt	P14735	Q8CGB9
RefSeq (mRNA)	NM_001165946	NM_031156
RefSeq (protein)	NP_001159418	NP_112419
Location (UCSC)	Chr 10: 92.45 – 92.57 Mb	Chr 19: 37.27 – 37.34 Mb
PubMed search	[1]	[2]