STAT6
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Signal transducer and activator of transcription 6 (STAT6) is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.[1][2]
In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.[3]
Interactions
STAT6 has been shown to interact with:
- CREB-binding protein,[4][5]
- EP300,[4]
- IRF4,[6]
- NFKB1,[7]
- Nuclear receptor coactivator 1,[5][8] and
- SND1.[9]
Pathology
- Gene fusion
- Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors.[10]
- Amplification
- STAT6 is amplified in a subset of dedifferentiated liposarcoma.[11]
See also
References
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Further reading
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External links
- STAT6 Transcription Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
