Masoprocol

Masoprocol

File:Masoprocol.svg
Systematic (IUPAC) name
4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
Clinical data
Trade names	Actinex
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: B (No risk in non-human studies)
Routes of administration	Topical
Pharmacokinetic data
Bioavailability	Very low
Identifiers
CAS Number	500-38-9 Y
ATC code	L01XX10 (WHO)
PubChem	CID: 71398
IUPHAR/BPS	4265
DrugBank	DB00179 Y
ChemSpider	64490 Y
UNII	7BO8G1BYQU Y
ChEBI	CHEBI:73468 N
ChEMBL	CHEMBL313972 N
Chemical data
Formula	C18H22O4
Molecular mass	302.365 g/mol
SMILES Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2
InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ Y Key:HCZKYJDFEPMADG-TXEJJXNPSA-N Y
NY (what is this?)  (verify)

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.

External links

• MedlinePlus Drug Information
• Actinex entry in the public domain NCI Cancer Dictionary