Dishevelled
From Infogalactic: the planetary knowledge core
| Dishevelled specific domain | |||||||||
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| File:PBB Protein DVL1 image.jpg | |||||||||
| Identifiers | |||||||||
| Symbol | Dishevelled | ||||||||
| Pfam | PF02377 | ||||||||
| InterPro | IPR003351 | ||||||||
| PROSITE | PDOC50841 | ||||||||
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Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors.[1] It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs.[2]
Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.[2]
Contents
Members
There are three human genes that encode for the dishevelled proteins:[3]
Overview of signal transduction pathways involved in apoptosis.
Example
Alignment of dishevelled-specific domain
References
External links
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Look up dishevelled in Wiktionary, the free dictionary. |
- dishevelled proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
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