C-type lectin
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A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin.[2] The C-type designation is from their requirement for calcium for binding.[3] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.[4][5]
Classification
Drickamer et al. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein.[6] This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV).[7] Most recently, three further subgroups were added (XV to XVII).[2]
| Group | Name | Associated domains |
|---|---|---|
| I | Lecticans | EGF, Sushi, Ig and Link domains |
| II | Asialoglycoprotein and DC receptors | None |
| III | Collectins | None |
| IV | Selectins | Sushi and EGF domains |
| V | NK - cell receptors | None |
| VI | Multi-CTLD endocytic receptors | FnII and Ricin domains |
| VII | Reg group | None |
| VIII | Chondrolectin, Layilin | None |
| IX | Tetranectin | None |
| X | Polycystin | WSC, REJ, PKD domains |
| XI | Attractin (ATRN) | PSI, EGF and CUB domains |
| XII | Eosinophil major basic protein (EMBP) | None |
| XIII | DGCR2 | None |
| XIV | Thrombomodulin,CD93,CD248 | EGF domains |
| XV | Bimlec | None |
| XVI | SEEC | SCP and EGF domains |
| XVII | CBCP/Frem1/QBRICK | CSPG repeats and CalX-beta domains |
CLECs include:
- CLEC1A, CLEC1B
- CLEC2A, CLEC2B, CD69 (CLEC2C), CLEC2D, CLEC2L
- CLEC3A, CLEC3B
- CLEC4A, CLEC4C, CLEC4D, CLEC4E, CLEC4F, CLEC4G, ASGR1 (CLEC4H1), ASGR2 (CLEC4H2), FCER2 (CLEC4J), CD207 (CLEC4K), CD209 (CLEC4L), CLEC4M
- CLEC5A
- CLEC6A
- CLEC7A
- OLR1 (CLEC8A)
- CLEC9A
- CLEC10A
- CLEC11A
- CLEC12A, CLEC12B
- CD302 (CLEC13A), LY75 (CLEC13B), PLA2R1 (CLEC13C), MRC1 (CLEC13D), MRC2 (CLEC13E)
- CLEC14A
- CLEC16A
- CLEC17A
The "NK Cell lectin-like receptors" are a very closely related group:[8]
- KLRA1
- KLRB1 (CLEC5B)
- KLRC1, KLRC2, KLRC3, KLRC4
- KLRD1
- KLRF1 (CLEC5C)
- KLRG1 (CLEC15A), KLRG2 (CLEC15B)
- KLRK1
Additional proteins containing this domain include:
- AGC1; ATRNL1
- BCAN
- CD248; CD72; CD93; CHODL; CL-K1-Ia; CL-K1-Ib; CL-K1-Ic; CLECSF5; COLEC10; COLEC11; COLEC12; CSPG3
- FCER2; FREM1; HBXBP;
- LAYN; LOC348174; LOC728276
- MAFA; MBL2; MGC34761; MICL; MRC1L1
- OLR1
- PAP[disambiguation needed]; PKD1; PKD1L2; PLA2R1; PRG2; PRG3
- REG1A; REG1B; REG3A; REG3G; REG4
- SELE; SELL; SELP; SFTPA1; SFTPA2; SFTPA2B; SFTPD; SRCL
- THBD
- VCAN
References
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<references />, or <references group="..." />External links
- Functional Glycomics Gateway, a collaboration between the Consortium for Functional Glycomics and Nature Publishing Group
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ C-Type Lectin at the US National Library of Medicine Medical Subject Headings (MeSH)
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ NK Cell Lectin-Like Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
