ADAMTS12

ADAM metallopeptidase with thrombospondin type 1 motif, 12
Identifiers
Symbols	ADAMTS12 ; PRO4389
External IDs	OMIM: 606184 MGI: 2146046 HomoloGene: 12808 GeneCards: ADAMTS12 Gene
Gene ontology Molecular function • metalloendopeptidase activity • protein binding • zinc ion binding Cellular component • proteinaceous extracellular matrix • extracellular matrix Biological process • cell-matrix adhesion • cell migration • proteoglycan catabolic process • negative regulation of chondrocyte differentiation • regulation of inflammatory response • proteolysis involved in cellular protein catabolic process • cellular response to interleukin-1 • cellular response to tumor necrosis factor • cellular response to BMP stimulus • regulation of endothelial tube morphogenesis • negative regulation of hepatocyte growth factor receptor signaling pathway • negative regulation of cellular response to vascular endothelial growth factor stimulus • negative regulation of cellular response to hepatocyte growth factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE ADAMTS12 221421 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81792	239337
Ensembl	ENSG00000151388	ENSMUSG00000047497
UniProt	P58397	Q811B3
RefSeq (mRNA)	NM_030955	NM_175501
RefSeq (protein)	NP_112217	NP_780710
Location (UCSC)	Chr 5: 33.52 – 33.89 Mb	Chr 15: 11.06 – 11.35 Mb
PubMed search	[1]	[2]

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.

External links

• The MEROPS online database for peptidases and their inhibitors: M12.237