TTRAP
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). TRAF and TNF receptor-associated protein is a protein that in humans is encoded by the TTRAP gene.[1][2]
Function
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.[2]
Interactions
TTRAP has been shown to interact with ETS1,[3] TNFRSF1B[4] and CD40.[4]
References
Further reading
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