Poly(beta-D-mannuronate) lyase

poly(beta-D-mannuronate) lyase
Identifiers
EC number	4.2.2.3
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Alginate_lyase2
File:PDB 1vav EBI.jpg crystal structure of alginate lyase pa1167 from pseudomonas aeruginosa at 2.0 a resolution
Identifiers
Symbol	Alginate_lyase2
Pfam	PF08787
InterPro	IPR014895
SCOP	1uai
SUPERFAMILY	1uai
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Alginate_lyase
Identifiers
Symbol	Alginate_lyase
Pfam	PF05426
SCOP	1uai
SUPERFAMILY	1uai
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In enzymology, a poly(beta-D-mannuronate) lyase (EC 4.2.2.3) is an enzyme that catalyzes the chemical reaction

Eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is poly(beta-D-1,4-mannuronide) lyase. Other names in common use include alginate lyase I, alginate lyase, alginase I, alginase II, and alginase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HV6, 1J1T, and 2CWS.