p21-activated kinases
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p21 activated kinases (PAKs) are members of a family of enzymes.[1] They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.
Members include:
- PAK1, regulating cell motility and morphology[2]
- PAK2, possibly playing a role in apoptosis[3]
- PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity[4]
- PAK4, a mediator of filopodia formation[5]
- PAK5, a mediator of filopodia formation[6]
- PAK6, involved in cytoskeleton rearrangement[7]
References
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<references />, or <references group="..." />External links
- PAK Info with links in the Cell Migration Gateway
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- ↑ p21-Activated Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
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- ↑ http://www.ncbi.nlm.nih.gov/gene/57144
- ↑ http://www.ncbi.nlm.nih.gov/gene/56924
