KLRA1

From Infogalactic: the planetary knowledge core
(Redirected from Ly49)
Jump to: navigation, search
killer cell lectin-like receptor, subfamily A, member 2
Identifiers
Organism Mus musculus
Symbol Klra2
Alt. symbols Ly49b; Klra30
Entrez 16633
RefSeq (mRNA) NM_008462.5
RefSeq (Prot) NP_032488.4
UniProt Q60660
Other data
Chromosome 6: 131.22 - 131.25 Mb
Killer cell lectin-like receptor subfamily A pseudogene 1
Identifiers
Symbol KLRAP1
Alt. symbols KLRA1; Ly49; LY49L; Ly-49L
Entrez 10748
HUGO 6372
OMIM 604274
RefSeq NM_006611
UniProt O75889
Other data
Locus Chr. 12 p12-p13

Ly-49 receptors or killer cell lectin-like receptor subfamily A (KLRA), are a class of natural killer cell receptor.[1][2] Ly-49 proteins are a diverse set of C-type lectins that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host MHC class I as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit cytotoxic T cell mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells.

The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).[3][4]

References

  1. Lua error in package.lua at line 80: module 'strict' not found.
  2. Lua error in package.lua at line 80: module 'strict' not found.
  3. Lua error in package.lua at line 80: module 'strict' not found.
  4. Lua error in package.lua at line 80: module 'strict' not found.

External links


<templatestyles src="Asbox/styles.css"></templatestyles>