File:Metformin synthesis.svg

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Summary

<a href="https://en.wikipedia.org/wiki/Chemical_synthesis" class="extiw" title="w:Chemical synthesis">Chemical synthesis</a> of <a href="https://en.wikipedia.org/wiki/metformin" class="extiw" title="w:metformin">metformin</a>, as reported by Seymour L. Shapiro et al. in 1959.
<a href="https://en.wikipedia.org/wiki/Dimethylamine" class="extiw" title="w:Dimethylamine">Dimethylamine</a> (1) and <a href="https://en.wikipedia.org/wiki/2-cyanoguanidine" class="extiw" title="w:2-cyanoguanidine">2-cyanoguanidine</a> (2) react at 120–140°C to form metformin (3).
Created using <a rel="nofollow" class="external text" href="http://www.acdlabs.com/download/chemsk.html">ACD/ChemSketch 10.0</a>, <a href="https://en.wikipedia.org/wiki/Inkscape" class="extiw" title="w:Inkscape">Inkscape</a> and <a href="https://en.wikipedia.org/wiki/vim_(text_editor)" class="extiw" title="w:vim (text editor)">vim</a>.

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	04:46, 9 January 2017		525 × 168 (12 KB)	127.0.0.1 (talk)	<a href="https://en.wikipedia.org/wiki/Chemical_synthesis" class="extiw" title="w:Chemical synthesis">Chemical synthesis</a> of <a href="https://en.wikipedia.org/wiki/metformin" class="extiw" title="w:metformin">metformin</a>, as reported by Seymour L. Shapiro <i>et al.</i> in 1959.<br><a href="https://en.wikipedia.org/wiki/Dimethylamine" class="extiw" title="w:Dimethylamine">Dimethylamine</a> <b>(1)</b> and <a href="https://en.wikipedia.org/wiki/2-cyanoguanidine" class="extiw" title="w:2-cyanoguanidine">2-cyanoguanidine</a> <b>(2)</b> react at 120–140°C to form metformin <b>(3)</b>.<br>Created using <a rel="nofollow" class="external text" href="http://www.acdlabs.com/download/chemsk.html">ACD/ChemSketch 10.0</a>, <a href="https://en.wikipedia.org/wiki/Inkscape" class="extiw" title="w:Inkscape">Inkscape</a> and <a href="https://en.wikipedia.org/wiki/vim_(text_editor)" class="extiw" title="w:vim (text editor)">vim</a>.

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