File:Bi-directional modulation of AMPA receptor.png
Summary
| Description |
A model for the mechanisms of depotentiation (DP) and de novo LTD. Rectangles represent AMPARs, open circles transmitter vesicles. (A) DP is due to a reduction in the number of surface-expressed AMPARs (DPN) when preceded by LTPN. Depression below the original baseline is due to a further reduction in AMPA receptor number causing a complete loss of postsynaptic receptors at some synapses. De novo LTD is due to the same mechanism. (B) DP is due to a reduction in γ (DPγ) when preceded by LTPγ. |
|---|---|
| Source |
Andreas Lüthi, Martin A Wikström, Mary J Palmer, Paul Matthews, Tim A Benke, John TR Isaac, Graham L Collingridge. Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity. BMC Neuroscience 2004, (5)44. doi:10.1186/1471-2202-5-44 |
| Date |
02:57, 7 December 2009 (UTC) |
| Author |
Lüthi, Martin A Wikström, Mary J Palmer, Paul Matthews, Tim A Benke, John TR Isaac, Graham L Collingridge |
| Permission (Reusing this file) |
http://www.biomedcentral.com/info/about/license |
Licensing
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